The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex. used were of analytical grade. Preparation of TDDS. Composition of formulation of transdermal patches was showed in Table 1. The polymeric solution (10%. The purpose of this research work was to Formulation and evaluation of transdermal drug systems (TDDS) which can deliver medicines via the skin portal to.

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The intra-day variability was checked at three time points on the same day, and the inter-day variability was checked on three consecutive days.

The lower moisture content in the formulations helps them to remain stable and become a completely dried and brittle film.

The weight of formulation F7 was Preparation of the rate-controlling membranes We used a previously reported method that had already been used in our lab to prepare three rate-controlling membranes Figure 2that is, membrane M1 made of monomers A, B and C1 Zhan et al.

Comparison release of the developed evaluatoin with the controlling group. So, the PVA was chosen to perform latter experiment.

Formulation and Evaluation of Transdermal Patch of Repaglinide

Fourier transform infrared FTIR technique was used to study the physical and chemical interaction between drug and excipients. The receptor compartment of the diffusion cell was filled with phosphate buffer pH 7. As polyacrylates are non-degradable polymers, they are controlled drug molecules across lf pores in the membrane instead of degradation, erosion or dissolution of the polymer.


In Vitro Permeation Study [ 10 ] An in vitro permeation study was carried out by using Franz diffusion cell. This is the first report on transdermal drug delivery of TPM and found to be effective compared to previously reported dosage forms of TPM. In this design, tddw independent factors were evaluated, each at 3 levels, and experimental trials were performed for all 9 possible combinations.

International Scholarly Research Notices

Transdermal formukation of highly lipophilic drugs: Actually, the excised animal skin could not represent the real permeation of drugs transporting through human skin. Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to Vormulation the present study, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising TPM with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent casting technique.

The permeation of ISDN through different ratecontrolling membranes. Materials and Methods 2.

Formulation and evaluation of transdermal drug delivery of topiramate

Calibration curve of TPM was constructed and found to be leniar and microscopic pictures of formulations with different polymers were compared. Repaglinide was received as a gift sample from Torrent Pharmaceutical Ltd.

Recent advances in transdermal drug delivery. Formulation and evaluation of controlled-release transdermal patches of theophylline-salbutamol sulfate. Pressure-sensitive adhesives for transdermal drug delivery systems. Preparation of the drug reservoir containing penetration enhancer The preparation of the drug reservoir with a penetration enhancer followed the same procedure as the preparation of the PVA reservoir layer.


Polyvinylpyrrolidine, cellulose acetate phthalate CAPcarbopoltween 80, chloroform, dichloromethane were purchased from Accord labs, Secunderabad. Accuracy The accuracy was determined by recovery studies. Drug release kinetics were analyzed by various mathematical models such as a zero-order and first-order kinetic models; Higuchi and Korsmeyer—Peppas models to ascertain the evalluation of drug release.

Formulation and evaluation of transdermal drug delivery of topiramate

Comparative drug release profiles of transdermal drug delivery system with Eudragit L Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro. Topical pharmacology and toxicology of dimethyl sulfoxide 1. Formulatino plot of concentrations of the drug versus absorbance was plotted.

The data indicate that the release profile of the drug is strongly dependent on the selected independent variables. Membrane M1 also showed higher permeation rates compared to M2 and M3 when the tested drug was clonidine HCl Zhan et al. SC lipid model membranes designed for studying impact of ceramide species on drug diffusion and permeation, Part III: Eudragit Lmatrix dispersion system, oleic acid, penetration tdfs, permeation studies, polyvinylpyrrolidone.

Where Q t is the amount of drug released in time tK H is release rate constants.