Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.
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Purchase access Subscribe to JN Learning for one year. J Am Acad Dermatol ; Her medical history revealed that she had been treated with D-penicillamine for Wilson disease for more than 20 years.
After 2 months of tazarotene therapy, the condition of patient 1 was greatly improved Figure 3 and that of patient 2 was moderately improved. Previous treatments with perfoeans antifungal and topical steroid were ineffective. You can help Wikipedia by expanding it.
A case of elastosis perforans serpiginosa. In addition, they are mostly single, and the presence of numerous scattered plaques is atypical. Retrieved from ” https: Create a personal account to register for email alerts with links to free full-text articles. D-penicillamine induced elastic fiber alteration may not always manifest clinically as EPS. A marker of long-term administration of penicillamine.
These lesions were associated with a 6-cm-long scar on the posterolateral aspect of the left side of the neck. A case of elastosis perforans serpiginosa associated with pseudoxanthoma elasticum. Moreover, attempts to treat EPS with oral isotretinoin, local corticosteroid injections, electrocoagulation, cryotherapy as well as UVB irradiation were performed but the effect was poor [ 34 ].
That group of diseases also includes reactive perforating collagenosis, perforating folliculitis or Kyrle disease. We report a case of D-penicillamine induced widespread alteration in skin elastic tissue with distinct histopathologic features.
Because multiple therapies had failed in both cases, the patients were offered a trial of 0. The patient had been treated with oral cephalexin for 2 weeks and topical erythromycin solution for several weeks, without improvement. Imiquimod therapy for elastosis perforans serpiginosa. In the transepidermal channel, and particularly in its lower part, basophilic degeneration mass consisting of keratinocytes, remainings of crumbled inflammatory cells and elastic fibers can be detected.
Elastosis perforans serpiginosa: a review of the literature and our own experience
Open in a separate window. This condition is inherited in an autosomal dominant manner. This page was last edited on 2 Mayprforans Elastosis perforans serpiginosa EPS is a rare disorder classified as a primary perforating dermatosis. Conflict of interest The authors declare no conflict of interest.
Gomori methenamine silver stain and D-PAS stain were both negative for fungal elements.
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In addition, discontinuing penicillamine therapy does not guarantee preventing further development of EPS lesions in patients undergoing penicillamine therapy 15 J Am Acad Dermatol. The skin at the entrance of the tunnel accumulates chronic inflammatory infiltrate composed often of giant cells [ 1112 ].
Treatment of elastosis perforans serpiginosa with the flashlamp pulsed dye laser. National Slastosis for Biotechnology InformationU.
Elastosis perforans serpiginosa, Therapeutics. Expression of the kDa elastin receptor in perforating skin disorders. Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s disease with penicillamine.
Elastosis perforans serpiginosa | DermNet NZ
Received Jan 15; Accepted Feb A year-old woman presented with a 2-year history of an eruption on the anterior aspect of her neck and right arm that was relatively asymptomatic. Penicillamine-induced changes in elastic tissue of the upper respiratory tract.
Since it was first described by Lutz inEPS is one of four classic primary perforating disorders along with reactive perforating collagenosis, perforating folliculitis, and Elastoiss disease elawtosis.
A year-old man presented to Gangnam Severance Hospital with a 2-year history of skin eruptions on his neck, which were refractory to topical antifungal or steroid treatment. These papules first appeared 2 years ago and slowly increased in number. J Am Acad Dermatol.
Partially the parakeratotic keratin plug contains an addition of basophilic masses and crumbled nuclei of inflammatory cells. A year-old healthy man visited Gangnam Severance Hospital with hyperkeratotic papules on his anterior neck. This study was presented as a poster at the annual meeting of the American Academy of Dermatology, San Francisco, Calif, March This elastossis described as transepithelial elimination and results in a group of small reddish bumps.
Elastosis perforans serpiginosa is a rare skin disease characterized by transepidermal elimination of abnormal elastic fibers. In the second patient they observed a slight reduction serpiginsoa lesions after simultaneous treatment with 0. Response of elastosis perforans serpiginosa to pulsed CO2, Er: The fibers are compacted, twisted and fragmented, what can be clearly seen in the staining for elastic fibers such as in van Gieson staining. Increased elastic tissue and solar elastotic syndromes.
A year-old woman was referred to our institution for evaluation of a prutitic elaztosis scar” that had been present elxstosis the posterolateral aspect of the left side of her neck for 1 year.